Effects of Azelastine on Neutrophil Chemotaxis, Phagocytosis and Oxygen Radical Generation.
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概要
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The effects of azelastine, an orally active anti-allergic drug, on several inflammatory parameters of human neutrophils, including human neutrophil chemotaxis, phagocytosis and generation of reactive oxygen species (ROS), was examined. ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species investigated were superoxide radical anion (O<SUB>2</SUB><SUP>-</SUP>), hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) and hydroxyl radical (OH·). Azelastine significantly inhibited human neutrophil phagocytosis and the generation of O<SUB>2</SUB><SUP>-</SUP>, H<SUB>2</SUB>O<SUB>2</SUB>, OH· by human neutrophils. However, the drug did not markedly affect human neutrophil chemotaxis or the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that azelastine may exert an anti-inflammatory action by inhibiting human neutrophil phagocytosis as well as oxygen radical generation at the sites of inflammation.
- 公益社団法人 日本薬理学会の論文
著者
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Asada Yasuo
Department Of Dermatology Kansai Medical University
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Miyachi Yoshiki
Department Of Dermatology Graduate School Of Medicine Kyoto University
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Akamatsu Hirohiko
Department Of Applied Cell And Regenerative Medicine Fujita Health University Institute For Comprehensive Medical Science
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Niwa Yukie
Niwa Institute for Immunology
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Miyachi Yoshiki
Department of Dermatology, Tenri Hospital
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