Gastric Antisecretory Activity of 15(R)-15-Methylprostaglandin E2, Arbaprostil, in Dogs.

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概要

• 論文の詳細を見る

• The gastric antisecretory activity of 15(R)-15-methylprostaglandin E<SUB>2</SUB> (arbaprostil) was compared with that of natural prostaglandin (PG) E<SUB>2</SUB> in Pavlov pouch dogs. Arbaprostil significantly inhibited pentagastrin and food-stimulated gastric secretion when it was administered directly into the pouch at a dose of 10-30 μg/pouch and 30-300 μg/pouch, respectively. Natural PGE<SUB>2</SUB>, however, was inactive up to 1000 μg/pouch. The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease.

• 公益社団法人 日本薬理学会の論文

著者

• TAKANASHI Hisanori

  Department of Hospital Pharmacy

• Itoh Zen

  Laboratories for Gastroenterology, Institute of Endocrinology, Gunma University

関連論文

• Effects of Cisapride on Gastrointestinal Motor Activity and Gastric Emptying of Disopyramide
• Gastric Antisecretory Activity of 15(R)-15-Methylprostaglandin E2, Arbaprostil, in Dogs.
• Protective Effects of Arbaprostil against Indomethacin-Induced Gastric Lesions in Rats: Significance of Maintained Gastric Blood Flow.
• Acid-Promoted Epimerization of Arbaprostil, 15(R)-15-Methylprostaglandin E2, Elicits Gastric Antisecretory Activities in Rats.

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