Effects of Genistein on ATP Induced DNA Synthesis and Intracellular Alkalinization in Chang Liver Cells.

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概要

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• Extracellular ATP (adenosine 5'-triphosphate) produces a dose-dependent elevation of DNA synthesis concomitantly with raised intracellular pH (pH<SUB>i</SUB>) in quiescent monolayer Chang liver cells. Genistein produces a dose-dependent suppression of ATP-induced DNA synthesis without affecting cell viability (dead cell index ≈ 5%) or pH<SUB>i</SUB> elevation. The results suggest that (a) mitogenesis and pH<SUB>i</SUB> are not imperative correlates and (b) genistein is effective in inhibiting DNA synthesis whether due to growth factor or "non-growth factor" stimulation.

• 公益社団法人 日本薬理学会の論文

著者

• Bay Boon-huat

  Department Of Anatomy National University Of Singapore

• Bay Boon-Huat

  Department of Anatomy, National University of Singapore

• Wong Kim-Ping

  Department of Biochemistry, National University of Singapore

• Wong Kim-Ping

  Department of Biochemistry, Faculty of Medicine, National University of Singapore

• Sit Kwok-Hung

  Department of Anatomy, National University of Singapore

• Sit Kwok-Hung

  Department of Anatomy, Faculty of Medicine, National University of Singapore

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