Roles of Sulfhydryl Compounds in the Gastric Mucosal Protection of the Herb Drugs Composing Oren-Gedoku-To (a Traditional Herbal Medicine).

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概要

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• We investigated the involvement of sulfhydryl compounds in the cytoprotective effect of each component herb drug composing Oren-gedoku-to (OGT) against ethanol-induced gastric lesions and potential difference (PD) reduction in comparison with that of OGT in rats. Pretreatment with N-ethylmaleimide (NEM) significantly blocked the cytoprotective effects of OGT, <I>Coptidis rhizoma</I> and <I>Phellodendri cortex</I>, but did not block the cytoprotective effects of <I>Gardeniae fructus</I> and <I>Scutellariae radix</I>. The inhibitory effects of OGT, <I>Coptidis rhizoma</I> and <I>Phellodendri cortex</I> against the PD reduction disappeared in the presence of NEM or diethyldithiocarbamate (DDC), whereas NEM or DDC had little or no effect with <I>Gardeniae fructus</I> and <I>Scutellariae radix</I>. These results suggest that the gastric mucosal protection of <I>Coptidis rhizoma</I> and <I>Phellodendri cortex</I> may be ascribed to the reinforcement of mucosal barrier resistance through endogenous sulfhydryl compounds and DDC-sensitive compounds, but those of <I>Gardeniae fructus</I> and <I>Scutellariae radix</I> may be independent of NEM or DDC-sensitive compounds.

• 公益社団法人 日本薬理学会の論文

著者

• Suzuki Akira

  Kampo Research Laboratories, Kanebo, Ltd.

• Takase Hideki

  Kampo Research Laboratories, Kanebo, Ltd.

• Inoue Osamu

  Kampo Research Laboratories, Kanebo, Ltd.

• Saito Yuji

  Kampo Research Laboratories, Kanebo, Ltd.

• Yumioka Eizaburou

  Kampo Research Laboratories, Kanebo, Ltd.

関連論文

• Pharmacological Profile of Gastric Mucosal Protection by Marmin and Nobiletin from a Traditional Herbal Medicine, Aurantii Fructus Immaturus.
• Roles of Sulfhydryl Compounds in the Gastric Mucosal Protection of the Herb Drugs Composing Oren-Gedoku-To (a Traditional Herbal Medicine).
• A possible mechanism for the gastric mucosal protection by Oren-gedoku-to(OGT), a traditional herbal medicine.

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