Effect of a high dose of cimetidine on biliary, intestinal and fecal bile acids in rats.

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概要

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• Effect of an intraperitoneal injection of cimetidine at a daily dose of 160 mg/kg for two weeks on biliary lipid secretion, fecal excretion of bile acids and intestinal bile acids was studied in rats. Bile flow, biliary lipid secretion and fecal excretion of bile acids remained unchanged, while the pool size of bile acids decreased by cimetidine treatment. Chenodeoxycholic acid increased with a concomitant decrease of β-muricholic acid in the biliary bile acid composition of cimetidine-treated rats.

• 公益社団法人 日本薬理学会の論文

著者

• KAWATA Sumio

  Second Department of Internal Medicine, Osaka University Medical School

• TARUI SEIICHIRO

  Second Department of Internal Medicine, Osaka University Medical School

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• Effect of a high dose of cimetidine on biliary, intestinal and fecal bile acids in rats.

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