Pharmacomechanical coupling in vascular smooth muscle cells-an overview.

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概要

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• In vascular smooth muscles, neurotransmitters or autacoids produce contraction through activation of Ca<SUP>2+</SUP>-influx and release of Ca<SUP>2+</SUP> from intracellular store sites. These agonists appear to activate Ca<SUP>2+</SUP>-influxes in both voltage-dependent and voltage-independent manners. The release of Ca<SUP>2+</SUP> is thought to be linked to the action of inositol 1, 4, 5-trisphosphate. The phosphorylation of myosin light chain may be the mechanism for the Ca<SUP>2+</SUP>-induced contraction in smooth muscles. Some agonists only transiently increase cellular Ca<SUP>2+</SUP> and the phosphorylation of myosin, but they produce a sustained contraction in various vascular tissues. Hence, additional high Ca<SUP>2+</SUP>-sensitive mechanisms are no doubt involved in the contraction of vascular smooth muscle. In the present article, attention will be directed to the mechanisms and agonist-induced contraction in arterial smooth muscle.

• 公益社団法人 日本薬理学会の論文

著者

• Itoh Takeo

  Department Of Cellular And Molecular Pharmacology Graduate School Of Medical Sciences Nagoya City Un

• Itoh Takeo

  Department of Pharmacology, Faculty of Medicine,Kyusyu University

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• Pharmacomechanical coupling in vascular smooth muscle cells-an overview.
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