Reduced erythrocyte deformability in anemic rats with adjuvant arthritis.

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概要

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• Erythrocytes in anemic rats with adjuvant arthritis (AA) were less deformable compared with normal rats. Swelling of the spleen was noticed in anemic rats with AA. The treatment of anemic rats with recombinant human erythropoietin (r-HuEPO; 30 and 100 U/kg, i.v., for 5 days) resulted in a normalization of both the anemia and erythrocyte deformability. It is suggested that erythrocytes with reduced deformability may be sequestered by endothelial slits of the spleen, which may play a causative role in the anemia in rats with AA.

• 公益社団法人 日本薬理学会の論文

著者

• ASAI Fumitoshi

  Biological Research Laboratories II, Daiichi Sankyo Co., Ltd.

• Asai Fumitoshi

  Biological Research Laboratories, Sankyo Co., Ltd.

• Oshima Takeshi

  Biological Research Laboratories, Sankyo Co., Ltd.

関連論文

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• Recombinant Human Erythropoietin, but Not Iron Supplementation, Improved Anemia in Rats with Adjuvant-Induced Arthritis.
• Reduced erythrocyte deformability in anemic rats with adjuvant arthritis.

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