Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs.

スポンサーリンク

概要

• 論文の詳細を見る

• CS-905, (±)-3-(1 -diphenylmethylazetidin-3-yl)5-isopropyl 2-amino-1, 4-dihydro-6-methyl-4-(m-nitrophenyl)-3, 5-pyridine-dicarboxylate, is a novel dihydropyridine calcium blocker. Both CS-905 and nicardipine, when administered orally, produced a dose-dependent fall of blood pressure in conscious perinephritic hypertensive dogs. Unlike the hypotensive effect of nicardipine, that of CS-905 has a gradual onset and is long-lasting, with little increase in the heart rate and plasma renin activity (PRA). The lack of both tachycardia and increase of PRA is probably mostly due to the slow onset of antihypertensive action following CS-905.

• 公益社団法人 日本薬理学会の論文

著者

• OIZUMI Kiyoshi

  Biological Research Laboratories, Sankyo Co., Ltd.

• KOIKE Hiroyuki

  Biological Research Laboratories, Sankyo Co., Ltd.

• MIYAMOTO Masaaki

  Biological Research Laboratories, Sankyo Co., Ltd.

関連論文

• Effects of RS-1893, a novel cardiotonic agent, on central and peripheral hemodynamics in anesthetized rats.
• Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs.

スポンサーリンク