Effect of TRK-100, a prostacyclin analogue, on endotoxin-induced enhancement of blood coagulation in rats.

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概要

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• TRK-100 (0.03, 0.1 and 0.3 mg/kg, p.o.), a chemically stable analogue of prostacyclin, dose-dependently prevented blood coagulation and glomerular fibrin deposition which were enhanced by 4 hr infusion of endotoxin (100 mg/kg) in rats. In addition, TRK-100 suppressed the generation of endotoxin-induced tissue thromboplastin like activity in cultured human endothelial cells.

• 公益社団法人 日本薬理学会の論文

著者

• NISHIO Shintaro

  Basic Research Laboratories, Toray Industries, Inc.

• YAJIMA Motoyuki

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.

• SAKAI Akira

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.

• HORI Toshimitsu

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.

• OKUDA Toshiaki

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.

• MATSUBARA Tetsunori

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.

• SAITOH Katsuhiro

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.

関連論文

• Antithrombotic effect of TRK-100, a novel, stable PGI2 analogue.
• Effect of TRK-100, a prostacyclin analogue, on endotoxin-induced enhancement of blood coagulation in rats.

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