A CUMULATIVE EFFECT OF DIGITALIS ON THE HEART OF FROGS
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概要
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There are many studies concerning the cumulative effect of digitalis glycosides. Of old, Fraenkel (1) observed their cumulative effect in cats by the consecutive administration, and Gottlieb (2), Takayanagi (3), Hesse <I>et al</I>. (4) and Lendle (5) investigated the effect in frogs by the same way. Besides these, the experimental studies have been made by using a variety of methods in dogs, rabbits, pigeons and mice.<BR>In experiments on frogs, Takayanagi injected the cardiac glycosides for several days together and measured the total dose required to cause intoxication and the additional lethal dose of the drugs after the continuous infusion. Of late, Teodoru and Branceni (6) measured, first, the time needed for the cardiac glycosides to produce their effect by means of the perfusion method of the <I>in vivo</I> heart of frogs, and next, the time required for them to be washed away with the Ringer's solution, and then estimated an amount of the drugs accumulated.<BR>In those experiments, the amount of drugs is estimated mainly from the total lethal dose or the additional dose necessary for the occurrence of the lethal effect on the presumption that drugs would be stored intact in the cardiac muscle. But various questions are cast to this procedure, and at present, the mechanism of the cumulative action of cardiac glycosides is not clear.<BR>We framed our own plan of experiments with frogs on the assumption that a so called cumulative effect is different substantially between the cold-blooded animal like frogs and the warm-blooded animal such as cats and others, and that drugs may be stored as merely a substance in frogs.. Therefore, we administered first a given amount of cardiac glycosides to frogs, next injected an infusion of the leaves of digitalis purpurea one to ten days later and measured the time elapsed before the appearance of the systolic arrest of the heart <I>in vivo</I>.
- 公益社団法人 日本薬理学会の論文