Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits.
スポンサーリンク
概要
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MK-733 was found to prevent an increase of serum cholesterol levels in cholesterol-fed rabbits, and lovastatin also markedly inhibited their increase. MK-733 and lovastatin inhibited the increase of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol, and it slightly affected the high density lipoprotein (HDL) cholesterol levels. MK-733 and lovastatin suppressed the increase of serum phospholipid levels and slightly affected the triglyceride levels. MK-733 suppressed the development of atherosclerosis in coronary arteries and aorta, and lovastatin also diminished their development.
- 公益社団法人 日本薬理学会の論文
著者
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KAMEI Toshio
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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ISHIDA Fumiaki
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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Taguchi Kazuhiro
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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KOBAYASHI Masahiko
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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TAKAHASHI Takeo
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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WATANABE Keiko
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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OHMURA Ippei
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
関連論文
- Effect of simvastatin (MK-733) on sterol and bile acid excretion in rabbits.
- Effect of a New Calcium Entry Blocker, NB-818, on Delayed Neuronal Death in the Ischemic Gerbil Hippocampus.
- Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits.
- Effects of simvastatin (MK-733) on branched pathway of mevalonate.