Effects of prostaglandins E1,E2,F2.ALPHA. and I2 on adrenergic transmission in guinea pig pulmonary arteries.

スポンサーリンク

概要

• 論文の詳細を見る

• Effects of some prostaglandins (PGs) on adrenergic transmission were studied in guinea pig pulmonary arteries preloaded with 3H-norepinephrine. PGE<SUB>1</SUB> and PGE<SUB>2</SUB> at 0.1 to 100 nM concentration-dependently inhibited <SUP>3</SUP>H-release and contraction evoked at 5 Hz. This inhibition was antagonized by diphloretin phosphate. PGF<SUB>2α</SUB> at 1 to 100 nM had no effect on evoked <SUP>3</SUP>H-release and contraction. PGI<SUB>2</SUB> at 1 to 100 nM also failed to modify evoked <SUP>3</SUP>H-release, but markedly and concentration-dependently decreased evoked contraction. There exist presynaptic inhibitory PGE<SUB>1</SUB> and PGE<SUB>2</SUB> receptive sites on adrenergic neurons innervating guinea pig pulmonary arteries, whereas PGF<SUB>2α</SUB> and PGI<SUB>2</SUB> produced no effect on the adrenergic neurons.

• 公益社団法人 日本薬理学会の論文

著者

• Yasuda Gen

  Department Of Cardiology Yokohama City University Medical Center

• YASUDA Gen

  Department of Pharmacology, Yokohama City University School of Medicine

• MISU Yoshimi

  The Second Department of Internal Medicine, Yokohama City University School of Medicine

関連論文

• Relationship between salt intake and autonomic nervous system activity in young subjects
• Effects of prostaglandins E1,E2,F2.ALPHA. and I2 on adrenergic transmission in guinea pig pulmonary arteries.

スポンサーリンク