Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.

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概要

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• Basal pulse rate (PR) and systolic blood pressure (BP) in the tail artery of diabetic KK-CA<SUP>y</SUP> mice were compared with those of alloxan- or streptozotocin (STZ)-induced diabetic ddY mice. Significantly higher PR and BP were obtained by the above three kinds of diabetic states when compared with the pre-diabetic state (KK-CA<SUP>y</SUP>) or the non-diabetic state (ddY mice). The PR and BP alteration in diabetic KK-CA<SUP>y</SUP> mice were significantly different from the PR one in alloxanmice and from the BP one in STZ-mice, respectively. Both increases in PR and BP by the diabetic state suggest an anticholinergic state.

• 公益社団法人 日本薬理学会の論文

著者

• KIMURA Ikuko

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

関連論文

• Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.

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