Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). II. Mechanism of antiallergic action of TA-5707.
スポンサーリンク
概要
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Mechanism of the antiallergic action of 6-methyl-<I>N</I>-(1<I>H</I>-tetrazol-5-yl)-2-pyridinecarboxamide (TA-5707F) was studied using the water-soluble sodium salt (TA-5707). 1) TA-5707 administered p.o. at the dose ca. 3 times the ID50 for the PCA reaction did not inhibit capillary dye leakage induced on the rat skin by intracutaneous injection of histamine, serotonin, bradykinin and leukotriene D<SUB>4</SUB> (LTD<SUB>4</SUB>). 2) TA-5707, at concentrations above 10<SUP>-7</SUP> M, inhibited antigen-induced histamine release and dye leakage in the rat peritoneal cavity (passive peritoneal anaphylaxis). 3) TA-5707 inhibited both anaphylactic and compound 48/80-induced histamine release from the rat peritoneal mast cells, the IC50 being <I>ca</I>. 10<SUP>-5</SUP> M in both cases. It was concluded that TA-5707F exerts its antiallergic action by inhibiting the release of chemical mediators from sensitized cells.
- 公益社団法人 日本薬理学会の論文
著者
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TAKEYAMA SHIGEYUKI
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Ono Yasutoshi
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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TSUZURAHARA Kei
Biological Research Laboratory and Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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ISHIKAWA Setsuko
Biological Research Laboratory and Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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ISHIKAWA Setsuko
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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MURATA Takashi
Biological Research Laboratory and Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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KIKUCHI Matsuo
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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TAKEYAMA Shigeyuki
Biological Research Laboratory and Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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MURATA Takashi
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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