内リンパ電解質に関する実験的研究 : 第3報 アトロピン,ピロカルピン,アドレナリン及び重曹水の内リンパカリウム濃度に及ぼす影響について
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As the first step to clarify the mechanism of secretion of the endolymph, changes of the potassium concentration of the endolymph of guinea pigs by giving atropine, pilocarpine, adrenaline and solution of sodium bicarbonate were observed examined by the microanalytic method developed the author.The results were as follows : 1) The potassium concentration in 15 samples of the endolymph obtained from one inner ear of untreated guinea pigs ranged from 128 to 166.7 mEq/1. 2) The potassium concentration in four samples obtained from guinea pigs previo- usly by an injection of 0.1 % solution of atropine sulphate ranged from 133.8 to 153.0 rnEq/1. 3) The potassium concentration in five samples obtained from guinea pigs previo- usly treated by an injection of 1% solution of pilocarpine hydrochloride ranged from 163.1 to 172.8 mEq/l. 4) The potassium concentration in ten samples obtained from guinea pigs previo- usly treated by an injection 0.1% solution of adrenaline chloride ranged from 126.5 to 166.5 mEq/1. 5) The potassium concentration in five samples obtained from guinea pigs previo- usly treated by an injection of 7 % solution of sodium bicarbonate ranged from 115.7 to 132.1 mEq/1. 6) Compared with the untreated group, no significant change in potassium concent- ration was observed in the groups treated with atropine and adrenaline. The group treated with pilocarpine showed high potassium concentration but the group treated with sodium bicarbonate showed low concentration.The difference in po- tassium concentration was significant at the 1 % level.