慢性副鼻腔炎における上顎洞粘膜への抗生物質移行度に関する研究(筋注の場合)
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概要
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The amount and the route of distribution of antibiotics in the maxillary mucous membrane was studied when they were systemically adminstered for chronic maxillary sinusitis. Penicillin concentration in circulating blocd and the blood which was distributed to the maxillary mucous membrane were compared, after the intramuscular administration of crystalline sodium penicillin. The ratio of the concentration was 10: 7. For the determination of the Penicillin concentration in the maxillary mucous membrane, a new accurate method using the following formula was suggested by the author. S (unit /cc)I×15 (cc) /W(g)=S'(unit/g) S'/B × 100(%) = K K: Distribution Ratio. Obtained concentration of penicillin in the maxillary mucosa was compared in percentage with that of circulating blcod. This was called " The antibiotic distribution ratio to. the maxillary mucous membrane ". Majority of cases measured, showed the ratio of 40-80%. Having examined the relationship between the distribution ratio and histopathological findings of the maxillary mucous membrane, the following results were observed. In the cases with high percentage of the distribution ratio, the mucosa showed many blood vessels. In the cases with low percentage, a small amount of blood vessels, thickening of the wall of the blood vessels, obliteration of the blood vessels, the existence of ' Polster' etc. were observed. No significant relationship between this distribution ratio and other histopathological findings was recognized.
- 一般社団法人 日本耳鼻咽喉科学会の論文