上気道におけるCandidaの分布とその免疫血清学的並びに真菌学的研究
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A mycological examination was made on 132 outpatient of 13 loci in their upper respiratory tract and 173 strains of Candida were isolated in 41 cases (31.1%). A majority of these 41 cases consisted of the patients treated with Penicilline neburizer, the advanced-aged or cases of cancer, atrophic rhinitis and middle ear catarrh.As to the loci of isolation, Candida was isolated from the supratonsillar sossa and dental caries in 18.2 to 5% of the cases examined. These loci were considered to be the most common foci of infection of Candida together with the epipharynx of which a considerable number of colonies were usually proved by cultine.One hundred and seveny-three strains isolated were classified according to the Martin et al method. As a result, 120 strains were Candida albicans (70.5%). Moreover, Candida albicans was proved in each locus at the rate of 50 to 88.8%, showing the most predominant distribution in the upper respiratory tract.Mycological study revealed that 5 of 26 strains isolated were virulent and 4 of them were thermo-resistant for 5 minutes at 56°C.Immunological studies were also carried out on the 41 cases above mentioned and on the control group.The results obtained were as follows;1. Skin test was positive in not only the 41 cases but in control group at a cocentration of 0.1 to O.05γ.2. Precipitation reaction was positive in all cases examined at a concentration of 250γ/cc. At 125 γ/cc, however, only 5 out of the 41 cases showed positive result.3. Agglutination reaction was positive under 80-fold in all of the cases with exception of the 2 which showed positive result even at a concentration of 160-fold.4. Complement fixation reaction was negative in all of the cases.A few of the drugs generally used for external application in otolaryngological field of medicine were proved to have bacteriostatic effect for Candida in vitro.
- 社団法人 日本耳鼻咽喉科学会の論文
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