中耳感染による内耳病変の実験的研究
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Remarkable loss of bone conduction is often observed on the audiograms of the cases with otitis media or salpingitis. When these facts are considered, some of inner ear deafness might be due to the tympanogenic injury for the inner ear.To study the subject, animal experiments were carried out and researched for the histopathological changes of the middle and inner ears comparatively. For the comparison, author reported clinical cases recovered from total deafness following to acute middle ear inflammation.1) Group of bacterial infection: A suspension of Bac. proteus was injected into the right tym-panic cavities of guinea pigs.2) Group of allergic reaction: An egg white albumin was injected into the right tympanic cavities of sensitized guinea pigs.In both groups the left ears served as control. In all experimental animals the intravital fixation was performed with WITTMAACK's solution.The author used a new rapid method for embedding the labyrinth, i.e. Celloidin-Paraffin double.embedding. Two hundred serial sections of 5 thickness were made from each of 53 temporal bones and stained by CARAZZI's Haematoxylin-Eosin.The stained labyrinthine fluid containing the red and white blood cells and the fibrinoid subst-ances were found in all of the specimens for 48 hours following to the injection of egg white albumin as well as of bacterial suspension.Endolymph was stained in the basal turn of the cochlear duct and tunnel space in the cases examined 4 hours after the injection. The internal hair cells and the supporting cells were swollen in the allergic group.In all cases the markedly thickened round window membrane was infiltrated by inflammatory cells and the pathological changes above mentioned were observed most markedly in the perilabyrinthine fluid of Scala tympani adjacent to the round window membrane.The route of invasion to the cochlea could be found through the round window in all cases, but other routes could not be observed except only one case that showed the pathological changess of the oval window together with round window.These pathological changes in the inner ear showed a tendency to decrease within about 1 week but the changes in the organ of Corti still remained unchanged in the basal turn.
- 社団法人 日本耳鼻咽喉科学会の論文