副鼻腔炎粘膜(上顎洞,下鼻介,鼻茸)の 線維素融解作用について
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概要
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Fibrinolytic activity was measured in isotonic saline extract of such tissues as mucous memb-rane of maxillary sinus, inferior turbinate, nasal polyp, faucial tonsil, pharyngeal tonsil, and stomach mucous membrane.The mucous membrane of maxillary sinus, inferior turbinate, nasal polyp, faucial tonsil, phary-ngeal tonsil and stomach mucous membrane were taken from the patients ailing such diseases as sinusitis, tonsillitis, gastritis, gastric ulcer and gastric cancer.1. Results obtained indicated that(1) the strongest activity was observed in the extract from the mucous membrane of the inferior turbinate, (2) stronger activity was in the extract from the mucous membrane of the maxillary sinus, (3) fibrinolytic activity was weaker in the nasal polyp.(4) fibrinolytic activity was not observed at all in the faucial tonsil, the pharyngeal tonsil and the atomach.2., Fibrinolytic activity in the extract of nasal mucous membrane using isotonic saline solution was in the globulin fraction, not in the albumin fraction.3. Fibrinolytic activity of nasal mucous membrane was decreased to a certain extent by the addition of cystein; it was completely inhibited by the addition of ε-aminocapronic acid.4. This fibrinolytic activity belongs to the plasmin enzyme system.5. It is under the investigation that whether this fibrinolytic activity is due to plasmin itseff or the activator.6. The relation of the plasmin-like substance in the nasal and paranasal mucous membrane and the inflammatoy changes in the tissue was also discussed.
- 社団法人 日本耳鼻咽喉科学会の論文