フルオレセインによる蛍光を用いた喉頭顕微鏡下手術操作の評価--基礎的ならびに臨床的研究

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Capillary permeabilities of fluorescein and trypan blue were studied in the skin of rabbits and in the mucosa of the cheek pocket of hamsters. It was revealed that fluorescein was more permeable and extinguishable than trypan blue. In addition, it was observed that the permeability of fluorescein in the carrageenin granuloma was similar to that in normal mucosa. However, fluorescein remained longer in the carrageenin granuloma than in normal mucosa. Fluorescein test was clinically performed on various laryngeal lesions. Five ml of 10% fluorescein was injected intravenously and the lesions were visualized both immediately after the injection and also one and half hours or three hours after the injection under microlaryngoscopy using ultraviolet light. It was observed that longer period was necessary for the disappearance of fluorescence in the cases of polypoid vocal cords and pedunculate edematous polyps than in normal cases. Usefulness of fluorescein test in performing microlaryngosurgery especially for polypoid vocal cords was emphasized because the complete dissection of the diseased lesion was performed by suctioning the pathological substances under mucosa of the vocal cords which was stained by fluorescein.
社団法人日本耳鼻咽喉科学会の論文