嗅覚障害の治療法--特に副腎皮質ホルモン点鼻療法に関する臨床的研究

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概要

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• Recently the treatment of the olfactory disturbance has been investigated in many institutions extensively. However, the fruits of these studies were still far from perfect. In this study the treatment of the disturbance of the olfactory epithelium was investigated, because etiology of the olfactory disturbance was considered mostly as the abnormal change of the olfactory epithelium caused by nasal diseases (sinusitis, allergic or hypertrophic rhinitis etc).The results of treatment 1376 outpatients visiting the olfactory clinic of the Department of Otorhinolaryngology at Showa University were presented as follows:1) 1376 patients were divided into 4 types, respiratory olfactory disturbance, epithelial olfactory disturbance, combined olfactory disturbance and central olfactory disturbance, and 96% of them were of epithelial and combined type.2) In treatments 2 or 3 drops of 0.1% *-methasone or 0.1% dexamethasone nose drop were applied on olfactory mucosa in the patients, head down position as basic treatment.3) As the result of treatment, 87.5% of respiratory type, 68.6% of epithelial type and 75.7% of combined type were recovered completly or remarkably but none of the central type recovered.4) Side effects were studies after the administration of 5 ml/week of 0.I% dexamethasone or 0.1% *-methasone solution for 16 weeks, and the results of rapid ACTH test and the other adrenocortical function studies were normal.By this treatment, nearly 70% of the patients visiting our clinic were recovered completly or satisfactorily.Therefore nose-drops of adrenocortical hormone were considered very useful for the treatment of olfactory disturbances.

• 社団法人 日本耳鼻咽喉科学会の論文

著者

• 福島 淑子

  昭和大学医学部耳鼻咽喉科学教室

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