T & Tオルファクトメータを用いた嗅覚疲労実験

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Many of the patients of olfactory disturbance complained that they could smelled in a moment but the smell decreased rapidly. This phenomenon seemed that it caused of the olfactory fatigue. In this study, the relationship between olfactory fatigue and olfactory acuity was investigated for make clear this afternoon.The subjects of this study were 52 normal adults. The odorous for stimulus were CYCLOTENE and iso-VARELIC ACID which were the odorous of T & T olfactometer.The growing and recovering time of olfactory fatigue was measured under the following condition. The olfactory test paper was moisted with odorous and took placed nearly 1cm from the nasal tip of each subject. Subjects were blindfolded and took smelled of the odorous on test paper under rested respilation. A level of concentration of odorous was higher than that of the level in the subject. In the first inspection, the subjects were not explained about the difference. In the third inspection, the condition was the same of the second one, but two of different concentration odorous were used.Results obtained were as follows:In the first inspection, the measuring time of growing and recovering were fallen to pieces. In the second inspection, subjects were explained about both thresholds difference completely, so the data were not so fallen to pieces. In the third inspection, the time of growing and recovering at high concentration odorous was longer than that at low concentration odorous. Even though the data of second and third inspection were fallen to little pieces, but the ratio of growing time of fatigue in detection and recognition of several subjects were constant, which was 1.6.Therefore, it seemed that the data pieces were not originated in inspection method but in the structure of nasal cavity and the secretion of olfactory mucous membrane of several subjects. The data from third inspection were plotted on the graph and made the fatigue alteration with time of both concentrations. The fatigue at high concentration got rapidly in first term of fatigue, but changed inactive near in threshold level. The recovering rate of fatigue from detection to recognition were more rapid at high-concentration than lows.From the facts described above, the phenomenon that "patients could smelled in a moment but the smell decreased rapidly" were seemed that it originated in olfactory fatigue. Therefore, the investigation of this phenomenon in patients was very useful for diagnosis and treatment of olfactory disturbance.
社団法人日本耳鼻咽喉科学会の論文

T & Tオルファクトメータを用いた嗅覚疲労実験

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