咽頭に原発したIgA-& kappa型髄外性形質細胞腫 : 第1報臨床的および免疫学的検討とその文献的考察

概要

論文の詳細を見る
A 77 year-old male visited the Sapporo Medical College Hospital in February, 1980, complaining a tumor in the left posterior faucial pillar. Biopsy findings of the tumor revealed submucosal proliferation of pleomorphic plasma cells, but plasma cell did not increase its number in the bone marrow smear. The lesion was diagnosed as a extramedullary plasmacytoma of the pharynx and detailed examinations revealed that the patient was also suffering with pulmonary infiltration with eosinophilia and plasma cell dyscrasia.Although there was no increase in serum M-protein, a kappa type Bence-Jones protein was demonstrated in the concentrated urine specimen by immunoelectrophoretic method. An intracytoplasmic monoclonal immunoglobulin (type IgA-kappa) was also demonstrated by immuno-histochemical method in the tumor cells.We reviewed seventy-five cases with plasmacytoma of the head and neck region in the Japanese literature and found that five of these cases should be classified as the metastatic lesions of multiple myeloma, and four other cases were the solitary plasmacytoma of bone. Sixty-six of the reported cases were the "true" extramedullary plasmacytoma of the head and neck region and our case was found to be the eighth case located in the pharyngeal region.The patient is free of disease after treated by the combination of surgery and radiation therapy.
社団法人日本耳鼻咽喉科学会の論文