実験的溶連菌感染症の免疫学的研究

概要

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Immunological studies were performed on guinea pigs which were experimentally infected with group A or group C streptococci. The following results were obtained. 1. Group C streptococcus was less pathogenetic than group A streptococcus. 2. Immunoglobulin, especially IgG I, was markedly increased in both group A and group C streptococcal infection. 3. The ASLO titers were mesured more sensitively in group C streptococcal infection than in group A streptococcal infection by Latex ASL but more sensitively in group A streptoccocal infection than in group C streptococcal infection by Blue ASO. 4. In both group A and C streptococcal infection, the cell wall agglutination titers increased in late stage of inflammation. 5. The precipitating antibodies to SK-SD apeared even in early stage in group C strepto- coccal infection but in group A streptoccoccal infection, it appeared in late stage. By immuno- electrophoresis of SK-SD, it was found that the numbers of precipitin band were 1 to 2 in group A streptococcal infection and 3 in group C streptococcal infection. 6. One of these three precipitin bands which was characteristic in group C streptococcal infection, was situated from a1, globulin to albumin immunoelectrophoretically and was antibody to Fr. III of SK-SD. 7. It was shown that active component of delayed hypersensitivity to SK-SD found in Fr. II* in group A streptococcal infection, while it was found in Fr. III in group C streptococcal infection.