人口蓋扁桃の経年的変化に関する病理組織学的研究
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概要
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A histopathological study of nodules of lymphoid tissue and the crypts of human palatine tonsils removed from fetus, neonates and adults was made to clarify the relation of the development of the tonsils, as one of the lymphoid organs, to its reactive process against the pathogenic micro-organism.Specimens were collected from 247 cases of various ages ranging from a 17-week embryo to a 82-year-old patient, and were studied under light microscope. The results obtained were as follows;1) The fetal tonsils were made up of well organized nodules of lymphoid tissue and the crypts and elicited no particular reaction.2) The neonatal tonsils were characteristic in the development of the surrounding tissues of nodules of lymphocytes, reticulum cells and endothelial cells played an important part to the reactive process against the stimulating antigens, contrary to the adult tonsils in which plasma cells, secondary nodules and crypts played the same role.3) The tonsils in the embryo underwent profound alternation after 35 weeks.4) It was presumed that there was a close relation between the chronological change of histology of the tonsils and the alternation of the immunoglobulins and the bacterial flora usually found in the tonsils.5) Lymphoepithelial symbiosis in the crypts developed in the early stage of the embryo, and after seven months, reticular transformation and cellular infiltration of the epithelial lining of the cr ypts became prominent.6) Reticular transformation and cellular infiltration of the lining epithelium of the crypts coincided with the widening of the crypt orifice.7) The development of the tonsils terminated at between 7 months and 7 years of age and the tonsils were in a much more active state in this period of life. Though the tonsils had been thought to tend to become atrophic or degenerative with advancing age, they persistently showed a reactive alternation of and around nodules of lymphatic tissue even in the aged, and this fact suggested that the immunological functions of the tonsils in the aged differed from that in the young.
- 社団法人 日本耳鼻咽喉科学会の論文