猪初男教授開講十周年記念論文扁桃摘出による免疫グロブリンの変動に関する実験的研究
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概要
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The palatine tonsil is believed to have immunological function as lymphatic organ. To study its contribution to immunity, the changes of the serum immunoglobulin levels in rabbits before and after tonsillectomy were investigated. This fundamental study may be important to determine appropriate time of tonsillectomy. Rabbits were divided into two groups.1) Younger group Rabbits were tonsillectomized at 3 weeks to 12 weeks after birth, and serum immunoglobulins were measured sequentially and compared with those of not operated group.2) Adult group Streptococcus haemolyticus and Staplylococus aureus were injected into the palatine tonsils of the Adult rabbits, when ASL-O and ASK titer was getting higher, rabbits were tonsillectomized, and serum immunoglobulins, ASL-O and ASK titer were measured sequentially. The results were as follows;1) Younger groupi) Not operated group IgG and total immunoglobulin levels remained within normal range until 5 weeks after birth, and the highest levels were observed at 9 weeks after birth. IgM and IgA levels showed no significant changes in the course of their life.ii) Operated group The levels of IgG and total immunoglobulins were not changed or decreased 2-3 weeks after tonsillectomy. When animals were older than 7 weeks after birth, immunoglobulins levels were almost not affected by tonsillectomy. The IgM and IgG levels remained nearly at the not operated levels.2) Adult group IgG and total immunoglobulin levels tended to decrease in 2-3 wdeks, but showed only a few effects after operation. ASL-O and ASK titer increased temporalily and then decreased slowly.
- 社団法人 日本耳鼻咽喉科学会の論文