扁桃の慢性炎症が腎に及ぼす影響について(猪初男教授開講10周年記念論文)
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概要
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As to the relations between tonsillitis and nephritis, many clinical and experimental studies are known nowaday. We wish here to discuss about some renal pathologies of experimental animals sensitized for a certain long period by streptococci to make chronic tonsillitis similarly seen in human tonsils. First of all, we injected repeatedly the emulsions of high powered A-type hemolytic streptococci into the tonsils of rabbits, and after a long period of continuous sensitization, tonsils were removed and the supernatant of the extirpated tonsillar tissue emulsion was injected intravenously. Then renal biopsy was made and the renal tissues were studied histologically and immunofluorescently. Thus, we obtained the following results: 1) Post-streptococcal glomerulonephritis similar to that of human being could not obtained experi- mentally by the intratonsillar injections of hemolytic streptococci. 2) No definite interrelations were observed between renal pathology and ASLO titer nor urinary protein. 3) A certain degree of various pathological glomerular changes were observed in the renal tissues obtained by intravenous injections of extirpated tonsillar emulsions during the latter half of the sensitization period. 4) Renal glomeruli were thought to be always influenced by chronic tonsillar foci, so that the influence of chronic tonsillar inflammations to the onset, recurrence, and chronicity of nephritis could not be neglected.
- 社団法人 日本耳鼻咽喉科学会の論文