口蓋扁桃の免疫機能に関する研究 経静脈感作家兎口蓋扁桃の免疫組織学的考察

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概要

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• It has been widely accepted by many convincing experiments that the palatine tonsils consisting of a defensive mass of lymphoid tissue often show a clinical symptom signified by infection.The immunological characteristics of the tonsils have been discussed by many workers.The present study was attempted to know the immunological charactors of the palatine tonsils, when they were exposed to antigenic substances by application of direct fluorescent-antigen technique.Seven month-old male rabbits were intravenously immunized by ovalbumin for about a month.When the serum antibody exhibited the optimal titers, they were sacrified and the palatine tonsils were dissected.The specimens were fixed by cold 95% ethanol and made 4μ in thickness of paraffin sections.Fluorescein coupled antigen was prepared by Coons' method and absorbed by rabbit's liver powder after elution through the Serhadex column to remove non-specific staining.Following the successful staining, it was proved under fluorescence microscope that there were many cells stained strongly by the fluorescein coupled antigen in the tonsillar tissues from immunized rabbits.The fluorescent cells contained antibody were recognized around hilus, perifolliclar and subepithelial regions, while they were hardly observed in germinal center.These cells were mostly considered to be plasmacytic cells or lymphoid cells by histological findings.The results indicated that tonsils might contribute to immunological defense for invasion of microorganism.

• 社団法人 日本耳鼻咽喉科学会の論文

著者

• 斎藤 載

  和歌山県立医科大学耳鼻咽喉科学教室

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