慢性副鼻腔炎の原因としてのアレルギー : 慢性副鼻腔炎の皮膚反応, 洞粘膜のヒスタミン様物質とプラスミン
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概要
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The author studied on influence of allergy upn chronic sinusitis. Using various antigen, 123 patients with chronic sinusitis were examined by skin tests. Mucous membrane of the maxillary sinus in 65 cases of these was surgically removed, of which the extract was made. After the extract was reacted in vitro on positive antigen when the skin tests were positive, and on house dust when they were negative, histamine-like substance and plasmin values were calculated. Histological investigation was made on all of the cases and compared with those values.The following results have been obtained.1. Skin tests were positive in 21 per cent of all the cases with chronic sinusitis. This rate was almost the same as normal one. Positive reaction of skin tests was due to inhalative antigen, which consists of house dust.2. Histamine-like substance values in mucous membrane in the maxillary sinus were unrelated with reaction of antigen.3. Comparison of values for reacted and non-reacted plasmin by antigen in mucous membrane was performed, and no significant difference was shown.4. There was no constant relation between histamine-like substance value reacted by antigen and change of plasmin value.5. Histamine-like substance and plasmin were produced after reaction by antigen from cases of positive skin tests and after reaction by house dust from cases of negative skin tests. Comparision of histamine-like substance and plasmin values afteraboth of reactions was shown no significant difference.6. There was no particular finding histologically in cases with positive skin tests, increased plasmin value and increased histamine-like substance value.As mentioned above, there was no proof that allergy plays an important role in the cause of chronic sinusitis.
- 社団法人 日本耳鼻咽喉科学会の論文