慢性扁桃炎における血清 Properdin の研究
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概要
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The properdin system is a serologic protective system which contribute to natural resistance and does not belong to cellular protective system.The properdin titers were measured in order to explain the significance on every pathologic form of chronic tonsillitis, especially on the influence of properdin upon the mechanism of tonsillar focal infection.The method of the Zymosan assay modified by McNall was used.Average values of the serum properdin titer in the patients with focal chronic tonsillitis showed 77.1 units. These were lower than the 89.3 units in the patients with simple chronic tonsillitis and the 90.4 units in a control group of healthy persons. Those with rheumatic disease especially showed 74.6 units which was the lowest among the systemic diseases.In a focal group low values of the serum properdin (under the lowest of the serem properdin titers in a control group, 60 units) were seen in 31.8%, while 9.5% in a simple group.Low values in serum properdin were found more frequently in patients who showed an increase in Antistreptolysin-O titer and the properdin values in focal group were lower than those in the simple group.This is supposed that streptococcal infection gives the impeded effect to individual resistance.After focal elimination by tonsillectomy, the serum properdin remained much the same value as before tonsillectomy in both simple group and non-focal disease with chronic tonsillitis. But in the focal group, the serum properdin increased close to the nomal level and its value was in parallel with the degree of the recovery from systemic disease.Results from cutaneous injection made with the diagnosis solution of Paspat, focal group showed frequently an increase of serum properdin in coopration with reduced erythemata after tonsillectomy, while the simple group did not show these variations due to removal of tonsil.This increase of properdin suggests a recovery of natural resistance, because the patients became to possess no allergic aggresion on basis of bacterial infection.The properdin titers were varied in tonsillar nephritis, after tonsillar direct irradiation by ultrashort wave was given, and the titer in tonsillar rheumatic disease increased, after tonsillar focus was annuled by Impletol injection.From these results, it was attested that the tonsillar focus had the influence upon natural immunity and suggested that the properdin system had some roles in the mechanism of the tonsillar focal infection. Therefore the measurement of the properdin value has the effects to infer the immune stadium in the basis of the focal infection.
- 社団法人 日本耳鼻咽喉科学会の論文