嗅覚障害を有する慢性副鼻腔炎患者の病理組織学的研究 : 特にビタミンB1の生化学的研究 第1編副鼻洞粘膜の病理組織学的研究 第2編血中及び副鼻洞粘膜のビタミンB1定量 第3編副洞粘膜におけるビタミンB1分布
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On the patients with the chronic sinusitis accompanied with olfactory disturbances, macroskopic and pathological studies of the mucous menbrane of the maxillary and ethmoidal sinuses and also the biochemical experiments of thiamine were made. The followings are the results obtained: (1) Significant relationship was noticed between olfactory disturbance and the macroskopic changes of the paranasal mucous membrane. (2) A difinite relation was also formed bet- ween olfactory disturbance and the pathological changes of the paranasal mucous membrane. (3) By means of systematic pathological and histological studies of the paranasal mucous membrne with olfactory disturbance, the increase of eosinophile cells, dilatation of the vessels, and high degree of edema were remarkably observed, compared with the cases without olfactory disturbances. (4) The thiamine content in blood of patients suffered from chronic sinusitis with olfactory disturbances showed a tendency to decrease slightly compared with the controls. (5) By means of intravenous thiamine injection, a marked differences were recognized in the thiamine content in blood between total thiamine and combined from according to the stage of the olfactoay disturbances. (6) Relationship between the pathological changes in the paranasal mucous membrane and the amount of thiamine content were as follows: i) Total and combined thiamine content increased markedly in the purulent type, secondly in catarrhal and fibrous type. ii) Concering with the differences in grade of increase of thiamine by intravenous thiamine injection, an increase of total thiamine was most frequently observed in the purulent and fibrous type, secondary catarrhalic type and that of com- bined thiamine were catarrhal secondly in the purulent and fibrous type. (7) The thiamine distributed in the paranasal mucous membrane mostly consisted of the combined form, while the intensity of chiochrome fluorescence was strong in the epithelial layer, grandular cells, walls of the vessels and the parts with round cell infiltration and it was very weak in the parts of haemorrhage, edema and interstitial connective tissues. From these experiments, significant relationship between the pathological changes of the paranasal mucous membrane and the metabolism of thiamine was recognized.
- 社団法人 日本耳鼻咽喉科学会の論文