Thiamineの内耳液への移行に関する研究

概要

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In order to obtain some informations as to the origin and the absorption of the inner ear fluids, and to make foundamental study on the Vitamin B1 therapy for inner deafness, the anther investigated the transport of thiamine (Vitamin B1) to the inner ear fluids and cerebrospinal fluid of guinea pigs. Thiamine concentration was determined by using of Lactobacillus fermenti assay. The results obtained were as follows; 1) In normal guinea pigs, thiamine concentration in endolymph was about three times as much as in perilymph. 2) When thiamine derivatives were intramuscularly injected, it was found to be more easily transported to perilymph than to endolymph and cerebrospinal fluid. The rate of reduction of thiamine in view of time relaps was lower in endolymph than perilymph. The results are suggestive of existence of bloodendolymph barrier and inconsistent to the theory of derivation of perilymph from only endolymph or cerebrospinal fluid. 3) Thiamine diphosphate was demonstrated in endolymph by means of bioautography. 4) In constract to the control group, the transport of thiamine to endolymph was accelerated with a relatively weak stimulation (noise stimulation, SM and KM injection), while it was rather inhibited when the stimulation was strong.
一般社団法人日本耳鼻咽喉科学会の論文