Wegener氏肉芽腫症の1剖検例

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A case of Wegener's granulomatosis in 37 year- old male was reported. The patient died due to respiratory failure after one year from the onset.Remarkable clinical findings were exophthalm-us, voluminous crust accumulation in nasal cavity, plication were unremarkable.Presence of bronchial asthma and chronic sin-usitis in past history, alluded to the possible rela-tionship of these diseases to Wegener's granuloma-tosis.The patient had tonsillectomy in the past. It seems that a further investigation should be made as to the relationship of tonsillectomy and thymo-lymphatic system to the etiology of the rare dise-ase, though it has been hardly referred to in the literature.In regard to the treatment, Co60 irradiation, long-term administration of steroids and carcinost-atic agents more or less brought about symptomatic relief, while autovaccinization with staphylococcus aureus cultured from intranasal crusts was found to be ineffective.The autopsy revealed necrotizing granulomato-us lesions in nasal cavity, orbita, upper and lower respiratory tract, lung, and skin.Microscopically, angitis and thrombus were found in the lesions of respiratory tract, lung and skin.
一般社団法人日本耳鼻咽喉科学会の論文