家兎鼻粘膜移植の実験的研究
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概要
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Many cases of metaplasia to stratified squamous epithelium are seen in the atrophic rinitis. The maxillary epithelium also falls in metaplasia after the transplantion to the inferior turbinate by Kubo's maxilloturbinal plasty. We suppose that these changes are caused by many factors but the decrease of the blood supply in the mucosa plays an important role.A small graft from the septal mucosa of the nose in the rabbit was transplanted to the maxillary sinus. In 4 days the the transplanted graft falls in necrobiosis, but in 14 days regenerates a squamous like epithelium. In 30 days pseudostratified columnar epithelium and a few glands are seen and in 90 days the columnar epithelium matures containining many goblet cells and the glands increase in number.These regenerative changes co-relate closely with the reconstruction of the vascular network, which was confirmed quantitatively by the photomicrogram of the vascular network of the graft produced by injecting the latex solution from the carotid artery.The vascular network and the gland in the graft resemble to those in the original maxillary mucosa, and the epithelium becomes that of the nasal membrane.
- 一般社団法人 日本耳鼻咽喉科学会の論文