上顎癌の術前照射療法における臨床的および病理組織学的研究

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The cases of carcinoma of the paranasal sinuses were irradiated preoperatively with Teleobalt, and the effects of the preoperative irradiation were studied clinically and histopathologically.Tumor doses of the irradiation were measured with the miniature glass rods and ranged from 2000 rads to 4000 rads.Cases were maxillectomized within three weeks after irradiation, and the insufficiency of the doses of the preoperative irradiation was supplied post-operatively.Any outstanding change of the hematological and biochemical finding of the serum after the irradiation was not observed except for slight leucopenia.Even severe radiomucositis subsided usually within two weeks after irradiation, and no harmful effect to surgical procedure was affected. However, amount of the total blood loss during operation was somewhat greater than no-irradiated cases.In a few cases radionecrosis of the bones as well as the soft tissaes were observed. Postoperative courses were deranged in such cases.Histologically all cases were squamous cell carcinoma. The degeneration rate of tumor cells was increased, in parallel with the increase of the tumor doses.The remarkable findings of the invasion of the tumor cells into the endoneural and perineural lymphatic vessels were observed in five cases. This form of the extension of the tumor cells were considered as the cause of the obstinate neuralgia or numbness.
社団法人日本耳鼻咽喉科学会の論文