内耳血管の自律神経支配に関する組織化学的研究
スポンサーリンク
概要
- 論文の詳細を見る
The following problems were investigated using three histochemical techniques demonstrating mon-oamine oxidase (MAO), catecholamine (CA) and acetylcholinesterase (AchE) activity in the blood vessel of the guinea pig cochlea.1. The autonomic innervation on the blood vessel. A moderate activity of MAO and CA was found throughout the course of A cochleae propria up to its second branches. Acetylcholinesterase activity was not demonstrated in the wall of the vessel. The author made a conclusion from a view point of the neurohumoral theory that the adrenergic innervation was more predominant in the cochlear blood vessel than the cholinergic.2. An effect of the unilateral sympathectomy upon the MAO activity in the blood vessel.No demonstrable change in the enzym activity was observed in the wall of A. cochlea propria three days after operation. However, the activity increa-sed temporarily a week after operation.3. In vivo effects of MAO inhibitor β-phenyl-isopropylhydrazine hydrochloride on the enzyme activity and pigment granules in the stria vascularis.A marked increase in density of the pigment granule was observed in the upper turn of the cochlea without any inhibition of the MAO activity after an administration of the inhibitor.On the contrary, the density of the pigment decreased from the apical turn downwards with an inhibition of the enzyme after daily administrations of the inhibitor for 14 days.Serotonin injection showed an evident increase of MAO actirsty.
- 社団法人 日本耳鼻咽喉科学会の論文