モルモツトの眼窩下神経刺戟又は切断の際に口唇に生ずる変化についての研究
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概要
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Recently we have been studying what irritation given to nervous system especially to the autonomic nervous system, will affect the internal organs.Keisi Suzuki, a member of our depertment, has succeeded in obtaining some circulatory changes in the lung by irritating the infraorbital nerve with croton oil.On this experiment I have seen an ulcer on the upper lip of irritated side. I have tried to study the cause and inhibition of this ulcer.The result of the study revealed that the amputation of infraorbital nerve gave a higher incidence of ulcer than irritation with croton oil. This fact is thought to be due to the nutritional disturbance of the tissues through the dysfunction of autonomic fibers which accompany the infraorbital nerve.A single administration of chlorpromazine did not inhibit the production of the ulcer. However, the development of the ulcer was inhibited, when chlorpromazine and promethazine hydrochloride were conjointly used.It was consiconsidered that the mechanism of this inhibition is related to the supression of the unbalance of autonomic nerve, increasing circulatory blood volume in the tissue under its control.
- 社団法人 日本耳鼻咽喉科学会の論文