モルモツトの眼窩下神経過剰刺戟により生ずる遠隔臓器特に肺の変化及びその阻止に関する実験的研究

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A series of Studies on the autonomic nerve in the cervical and facial region have lately been carried out in our department. The author, working of the same subject, has performed a series of experiments in which irritating substances such as croton oil or silicon powder were put in direct contact with one of the suborbital nerves of the guinea pig. It was found that the exposure of the nerve to such stimulants caused always production of various changes, such as hyperemia, edema and/or hemorrhage in various remote organs, particualrly in the lungs. Those changes were more remarkable in the lung of the same side at that of the irritated nerve.The author believes that the mechanism of the production of these changes can be explained on the basis of Reillys theory, i.e., the irritation given to the nerve is transmitted through the sensory fibers contained in the autonomic nerve to bring about an axon reflex which, in turn, affects the vasomotor system to cause an increase in permeability of the capillaries, producing local edema, repture of the vessels, and necrosis of the surrounding tissue.The author also found that occurrence of these lesions can be prevented by the administration of chlorpromazine or promethazine hydrochloride which are known to block the action off the autonomic nerve before and after the exposure of the nerve to the irritation.
社団法人日本耳鼻咽喉科学会の論文