Thermal Noise ExposureによるCortis Organの病理組織学的研究 : 特に病変の初発部位とその拡がりかたについて

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Using the method of graphic cochlear reconstruction, the author conducted experiments to investigate localization and distribution of injuries of Cortis organ in the guinea pigs exposed to powerful thermal noise stimuli (135db, 125db, 120db).The results obtained were as follows:(1) The region of initial injury of Cortis organ was between the points of 8.4 and 9.0mm. from the basal end.(2) When the stimulus was stronger and/or when the duration of stimulation was longer, distribution of the injury was wider. There was a tendency to spread mainly toward the basal end.(3) Most of the pathological changes of Cortis organ following to the stimulation were progressive for about one week except minimal changes which were thought to recover to normal condition.(4) Following to the exposure to thermal noise, the pathological findings in the Cortis organ were seen primarily in the hair cells, secondarily in the supporting cells and subsequently in the mesothelial cells.
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