耳鼻咽喉科領域の局所止血に関する研究
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概要
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Bleeding encountered in the field of oto-rhino-laryngology is mainly parenchymatous in nature. However, very little has been studied about the method of local hemostasis.Using rabbits, the author studied the capillary blood flow in nasal mucosa and auricles under the microscope, and various local hemostatics were applied and their effects were observed. Results obtained were as follows:1) Capillary blood vessels in rabbit nasal septal mucosa were specific in their arrangement and in reticular pattern, being different from those in other parts of the body. The similar has been observed in human septal mucosa.2) The author selected Manetol, one of the tissue thromboplastin preparations, to inject into the tissue for the purpose of local hemostasis. Clinically, this was added to local anesthetic, which was Xylocaine with epirenamine and, injected into the tissue with favorable local anesthetic and hemostatic effect3) Hydrogen peroxide solution, an effective local hemostatic for parenchymatous bleeding, was applied and its hemostatic mechanism was studied. It was found that hemostatis was obtained by the occlusion of capillary lumina by oxygen bubbles.4) As a new local hemostatic, ferric ammonium sulfate (iron alum) solution was used and its prominent hemostatic effect and astrictive were reported. Olinicaliy, this solution showe no major destructive effect on the tissue, althougth some irritation to the tissue was noted. An attempt was made to remove its irritative effect so that it could be used routinely.
- 社団法人 日本耳鼻咽喉科学会の論文