上顎癌の病理組織学的研究(特に骨に対する影響に就いて)
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概要
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On former studies students observed chiefly carcinoma themselves, very few students observed of histopathological changes of the bone.The author observed in detail the changes of the maxillary bone, comparing the relation between bone and carcinoma in big section specimens by Dr. Miyakes method.The destruction of the bone by the carcinama and bony response were studied and their relation to the progress of the carcinoma was classified into four types.1) Bone is destructed and absorbed in direct contact with carcinoma nests.The author considers this is the most rapidly progressing type because proliferation of carcinoma cells is more rapid than that of connective tissue surrounding carcinomatous tissue.2) Bone is in contact with carcinoma nests through thin layer of connective tissue and there are no osteoclasts present.The authour considers that the progress of the carcinoma is relatively rapid in this type.3) Connective tissue is increased at the edge of the bone and osteoclasts and lacunere rsorption are present at the edge of the bone. Progress of the carcinoma is not rapid in this type.4) Formation of the new bone or osteoid tissue against the extension of the carcinoma. This is the most slowly progressing type of the carcinoma.On the relation between prognosis and destructive condition of bone, the prognosis is poor in cases which show dominantly rapid-progressing type and it is good in cases which show slowly progressing type.Other main results were as follows:1) Maxillary bone marrow is not red marrow but it is fatty marrow.2) Fiber connective tissue plays a rale in absorption and destruction of the bone.3) It seems like that foreign body giant cells appear in the neighbourhood of small pieces of dege. nerated bone, and absorb them.4) Even in the most destructive type, new bone formation is also recognized.5) Changes in bonemarrow against the extension of the carcinoma are sometimes recongnized in cases of direct contact of bony wall and carcinoma nests, in cases osteoclasts are present, in cases with fibrotic changes of bonemarrow, and in cases osteoid tissue is formed.
- 社団法人 日本耳鼻咽喉科学会の論文