内耳変性に関する実験的研究内耳両窓開放後の迷路の変性
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概要
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Lempert conducted the decompression operation as surgical treatment for unilateral menieres disease and published its excellent results. However, the evaluation of the results was thought to be inadequate from the standpoint of histopathology, that the present author performed the study on rabbits. In 3 to 12 months afthe the operation, histological specimens were prepared with vital fixation. Following results were obtained:(1) Oval and round windows fenestrated by operation were perfectly obturated by the connective tissue and newly formed bone.(2) Spiral ligament revealed remarkable calcification, and vascular stria showed squamous metaplasia and marked atrophy. Nevertheless, the Reissners membrane was bulged indicating hydrops labyrinthi. There was no great difference among specimens obtained from 3 to 12 months after the operation.(3) In Cortis organ, external hair-cells disappeared at first, and internal hair-cells began to disappear in about 6 months, most of them disappeared in 9 months. Sustentacular cells atrophied in 3 months, tended to collapse and disappear in over 9 months, and finally were supposed to passibly disappear.(4) In spiral ganglia, ascending degeneration took place, but was not extensive.(5) In vestibule and semicircular canal, static hair and statolithic membrane disappeared in about 6 months. Particularly statical macula revealed partial disappearance of hair-cells and vacuolation in 12 months.(6) The histological study demonstrated that the degeneration took place in the vestibule and cochlea due to decompression operation in the course of more than one year and progressed gradually, while there was no preventive method againgt hydrops labyrinthi.Therefore it is proper that the surgery to be named as degeneration operation rather than decompression operation.
- 社団法人 日本耳鼻咽喉科学会の論文