Effect of intravenously injected DTPA on cardiovascular system in rats.

概要

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The effects of intravenously injected DTPA (diethylenetriaminepentaacetic acid) to the cardiovascular system were examined pharmacologically in rats. When Zn-DTPA of the various doses (30-900μmol/kg) were injected intravenously to rats, the concentrations of total calcium, ionic calcium in serum decreased significantly 5min after the injection. This hypocalcemia continued 30min later. Correspond to the decreasing rates of total calcium and ionic calcium, the blood pressures raised significantly at 600μmol/kg dose, as compared to those of control group. The heart failure showing the prolong of Q-T wave in the electrocardiogram and the decreases of heart rates and weakened strokes were observed at 900μmol/kg dose, these changes were emphasized at 1, 200μmol/kg dose. On the other hand, no untoward findings were seen by Ca-DTPA injection.As a result, in the case that DTPA was injected intravenously to humans, it appeared that Zn-DTPA was more toxic than Ca-DTPA to cardiovascular system and then induced the damages of cardiovascular system such as the heart failure. Therefore, it should be prepared the available information on the blood pressure and heart diseases of radiation workers obtained from the medical checkup at regular intervals, providing for DTPA intravenous injection to humans.
日本保健物理学会の論文