The Effect of the Pre-operative Radiation in the Control of Local Recurrence in Rectal Carcinoma, and the Additional Effect of Hyperthermia.

概要

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The previous reports on preoperative radiation therapy for rectal carcinoma were reviewed. The radiation dosage in the previous reports ranged from 15 Gy to 60 Gy. The results of the reported studies showed that the preoperative radiation was considered to be effective when the radiation dosage was, more than 40 Gy. The radiation dosage of more than 40 Gy appeared to be effective in reducing the local recurrence rate and in improving the survival rate. However, appropriately controlled-studies should be carried out to confirm the effect of preoperative radiation therapy. The combined treatment of preoperative radiation and chemotherapy, or radiation and hyperthermia with or without chemotherapy is expected to be beneficial in enhancing the effect of radiation therapy. Such a combined treatment would be effective in reducing the time for preoperative radiation and possibly the side effects of radiation. Our results confirmed that the addition of hyperthermia to the preoperative radiation was effective in enhancing tumor necrosis. Future studies on the combined radiation and hyperthemia and/or chemotherapy are expected to prove its usefulness in preoperative treatment for rectal carcinoma.
日本大腸肛門病学会の論文