Clinical Impotance of the CA 19-9 Staining Pattern in Colorectal Cancer Tissue.

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This study was performed to investigate the relationship between the patterns of expression of the tumor marker CA 19-9 in colorectal cancer tissue and the prognosis after curative operation. Immunohistochemical staining of CA 19-9 in cancer tissue was performed in 71 colorectal cancer cases. The staining patterns were classified as follows ; (1) Negative C2D Grade I : staining at the apical surface (3) Grade II : staining in the cytoplasm (4) Grade III : staining in the stroma. 9 patients who have lewis Le (a-b-) phenotype were excluded. 7 patients classified as negative staining. 21 as Grade I, 11 as Grade 1 1, 23 as Grade III. Both the percentage of cases with recurrence and the cumulative non-recurrence rate were significantly higher in patients who showed Grade III patterns than in those with other staining patterns. 11 of the 23 patients who had recurrence showed serum CA 19-9 level of above normal during the follow up period. 9 out of these 11 patients showed staining pattecn of Grade III in the primary tumor. It is concluded the cases with staining pattern of Grade III tended to have a higher recurrence rate, and in these cases periodic measurement of serum CA 19-9 may be helpful for the detection of recurrence.
日本大腸肛門病学会の論文