Experimental Colorectal Cancer: The Relationship of Diets and Fecal Anaerobic Bacteria to Tumor Induction.

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概要

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• This study was undertaken to examine the effect of fat and fibers contained in diets on intestinal flora and tumor induction in rats.<BR>A total of 40 male Wister rats were maintained with one of 4 different diets: Group I with high fat and high fiber diet, Group II with high fat and fiberless diet, Group III with high fiber and fatless diet and Group IV with diet without fat and fibers.<BR>After feeding different diets for 5 weeks, these groups were further subdivided in accor-dance with the type of carcinogens, 1, 2-dimethylhydrazine (20 mg/kg/week) or EDTA, administered over 10 consecutive weeks. Anaerobic bacteria were evaluated at 4, 11 and 24 weeks after initiation of feeding the diets. All rats were killed and autopsied at 30 feeding weeks.<BR>The value of anaerobic bacteria was high in rats fed high fat diets and low in those fed high fiber diets. Compared with control group, anaerobic bacteria indicated a rather low value in cancer-bearing rats except for Group III.<BR>High fat diets were accompanied by a high risk for total tumor induction and diets without fat by a low risk, but Group IV without fat and fibers indicated an almost identical cancer volume with Group I fed high fat and high fiber diet.<BR>These results suggest that dietary fat increases anaerobic bacteria and promotes carcinogenesis, but, on the other hand, dietary fibers dicrease anaerobic bacteria resulting in a suppressive effect on cancer growth in rats.

• 日本大腸肛門病学会の論文

著者

• 遠藤 和彦

  新潟大学第1外科

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• Experimental Colorectal Cancer: The Relationship of Diets and Fecal Anaerobic Bacteria to Tumor Induction.

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