The Serological and Histological Study of Laminin, as a Predictive Factor of Liver Metastasis of Colon Cancer.

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For the purpose of determing the ability of laminin to predict the advancement and metastasis of colon cancer, serum laminin levels were measured in 100 patints with colon cancer, and the tissue laminin was simultaneously stained in 57 of these patients. The positive rate of serum laminin was 63 %, which was higher than those of CEA, CA 19-9 and CA 125, and tended to increase with the advancing of clinical stage. In cases with liver metastases, the positive rate further increased to 84 %. As for fixation needed for tissue laminin stain, only frozen slices showed stable stainability. The possitive rate of tissue laminin stain became higher among more differenciated histlogical types. In relation to liver metastasis, a significantly higher incidence was observed among laminin stain-negative cases (p<0.01). As for the correlation between serum laminin and laminin stain, the combination of serum laminin-positive and tissue laminin stain-negative results was found to be a risk factor of liver metastasis. From these results, it was suggested that laminin can be used as a predictive factor of liver metastasis from colon cancer.
日本大腸肛門病学会の論文