Ulcerative colitis and colorectal carcinoma.

概要

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An association of longstanding ulcerative colitis and colorectal cancer is a well-recognized condition. <BR>Prognosis of colorectal carcinoma associated with ulcerative colitis is usually poor, because the early diagnosis is often difficult and curative resection is discouraged in most patients. <BR>Mucosal dysplasia has been appreciated as a marker indicating the association of carcinoma with ulcerative colitis, but controversies on the diagnostic criteria of mucosal dysplasia have still remained. The natural history of mucosal dysplasia is also uncertain. <BR>DNA flow cytometry or mucin histochemistry are also insufficient to detect the presence of carcinoma associated with ulcerative colitis. <BR>A surveillance program to detect colorectal cancer associated with ulcerative colitis and to establish the indication for "preventive" colectomy, based on clinical observation with endoscopy and on exact understanding of evolution and progression of colorectal carcinoma associated with ulcerative colitis will resolve above mentioned problems.
日本大腸肛門病学会の論文