大腸癌および大腸腺腫患者糞便の免疫学的便潜血反応陽性部位

概要

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In order to achieve appropriate methods of sample picking up for the screening of colorectal cancer patients, using immunological occult blood test. <BR>The whole feces of colorectal cancer patients voided at a single defecation was examined. About 42 samples were taken from multiple spots on surface and cutting section as well. Occult blood test was done using immunological method (OC-HEMODIA). <BR>In colonic cancer, fecal occult blood was positive about 80% of samples, no matter where the samples were picked up. In rectal cancer, 78.9% of samples from the surface of the feces were positive, whereas only 34.8% of samples from the cutting section were positive. (P <0.01). <BR>The ratio of positive spots on the surface was lower in following conditions : cancers without ulceration, Dukes A cancers, cancers less than 3cm in diameter and benign adenoma. <BR>The false negative rate was lowered, by testing samples obtained rubbing longitudinally on the fecal surface, therefore the sample taking of this fashion was thought to be suitable.