投与によるラット大腸癌の発生過程に関する研究

概要

論文の詳細を見る
Histopathologic and cytophotometric studies on changes of colonic mucosa in rats treated with dimethylhydrazine (DMH) disclosed that a significant increase in proliferative activity of mucosa had occurred 4 weeks before the appearance of histopathologic dysplasia, and 8 weeks prior to development of grossly visible invasive cancer. In the present study, 12 rats received subcutaneous injection of DMH in a dose of 15 mg/kg/week. Two rats each were killed at 6, 8, 10, 14, 18 and 22 weeks after initiation of DMH-treatment and their colon were examined grossy, histopathologically and cytophotometrically. Gross cancers developed in 3 out of 4 rats killed after the 18th week of the treatment, whereas histopathplogic dysplasia had appeared in rats killed after 14 weeks of the treatment and increased proliferative activity as well as appearance of over 4 C cells were observed already after 8 weeks of DMH-treatment.
日本大腸肛門病学会の論文